![]() ![]() Therefore, understanding the functional heterogeneity of the BMSC subpopulations under different physiological and pathological conditions could have major ramifications for global health. Meanwhile, the therapeutic effect of total BMSCs is often less effective partly due to their heterogeneity. However, diverse cell surface antigens and complex gene expression of BMSCs have indicated that BMSCs represent heterogeneous populations, and the natural characteristics of BMSCs make it difficult to identify the specific subpopulations in pathological processes which are often obscured by bulk analysis of the total BMSCs. ![]() The stemness and potential therapeutic effect of BMSCs have been explored extensively in recent years.
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